Productos Naturales: cáncer y parasitosis

Documentos

A libertia patinoi (Cuatrec.) Delprete & C.H.Perss. (Borojó): food safety, phytochemicals, and aphrodisiac potential
Although the western discovery of borojó [Alibertia patinoi Cuatrec. (Delprete & C.H.Perss.)] is as recent as 1948, its several traditional uses in gastronomy and medicine, and its fame as an aphrodisiac are long standing and strong: the “love juice” extracted from it is very appreciated in Col...
year: 2023 - type: Scopus - journal: SN Applied Sciences  - DOI: 10.1007/s42452-022-05251-1  - Google Schoolar: search

Xylosma G. Forst. Genus: Medicinal and Veterinary Use, Phytochemical Composition, and Biological Activity
Xylosma G. Forst. is a genus of plants belonging to the Salicaceae family with intertropical distribution in America, Asia, and Oceania. Of the 100 accepted species, 22 are under some level of conservation risk. In this review, around 13 species of the genus used as medicinal plants were found, main...
year: 2022 - type: Scopus - journal: Plants  - DOI: 10.3390/plants11091252  - Google Schoolar: search

Peach Palm (Bactris gasipaes Kunth.): Ancestral Tropical Staple with Future Potential
A pre-Columbian staple, Bactris gasipaes Kunth. is a palm tree domesticated around 4000 years ago, so appreciated that a Spanish chronicler wrote in 1545, “only their wives and children were held in higher regard” by the Mesoamerican natives. The peach palm is an integral part of the foodways an...
year: 2022 - type: Scopus - journal: Plants  - DOI: 10.3390/plants11223134  - Google Schoolar: search

Onoseriolide, from Hedyosmum racemosum, induces cytotoxicity and apoptosis in human colon cancer cells
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. The number of colon cancer patients is increasing, and new alternatives for treatment are important. We focused on the sesquiterpene lactone onoseriolide from Hedyosmum racemosum, which is widely used in traditional medicine. ...
year: 2021 - type: Scopus - journal: Natural Product Research  - DOI: 10.1080/14786419.2019.1690485  - Google Schoolar: search

Synthesis of 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) and evaluation of their antioxidant and anticancer activities
Background: Pyrazoles have attracted particular attention due to the diverse biological activities associated with this heterocyclic system, and some have been shown to be cytotoxic to several human cell lines. Several drugs currently on the market have this heterocycle as the key structural motif, ...
year: 2021 - type: Scopus - journal: BMC Chemistry  - DOI: 10.1186/s13065-021-00765-y  - Google Schoolar: search

Synthesis and evaluation of biological activities of bis(Spiropyrazolone)cyclopropanes: A potential application against Leishmaniasis
This work focuses on the search and development of drugs that may become new alternatives to the commercial drugs currently available for treatment of leishmaniasis. We have designed and synthesized 12 derivatives of bis(spiropyrazolone)cyclopropanes. We then characterized their potential applicatio...
year: 2021 - type: Scopus - journal: Molecules  - DOI: 10.3390/molecules26164960  - Google Schoolar: search

Tragia L. Genus: Ethnopharmacological Use, Phytochemical Composition and Biological Activity
Tragia L. is a genus of plants belonging to the Euphorbiaceae family with worldwide intertropical distribution, composed of more than 150 species. In this literature review, 26 species of the genus used as medicinal plants were found, mainly in East Africa and the Indian subcontinent, with a variety...
year: 2021 - type: Scopus - journal: Plants  - DOI: https://doi.org/10.3390/plants10122717   - Google Schoolar: search

Actividad Genotóxica de Solanum betaceum Cav Genotoxic Activity of Solanum betaceum Cav
Introducción y objetivo: Solanum betaceum Cav. pertenece a la familia Solanaceae. Su origen es andino, pero en la actualidad se distribuye en todo el mundo; se lo conoce como “chilto”, “tamarillo”, “tomate de árbol”, “tamamorro” y muchos otros nombres en distintos paises. Los fruto...
year: 2021 - type: Latindex Directorio - journal: Acta Toxicológica Argentina  - Google Schoolar: search

Study of a Selected Series of 3- and 4-Arylcoumarins as Antifungal Agents against Dermatophytic Fungi: T. rubrum and T. mentagrophytes
The main etiological agents in dermatophytosis of human skin and nails are Trichophyton, in particular Trichophyton rubrum (T. rubrum) and Trichophyton mentagrophytes (T. mentagrophytes). A new series of twenty-three 3- and 4-arylcoumarins was synthesized and the antifungal activities against clinic...
year: 2021 - type: Scopus - journal: ChemistrySelect  - DOI: 10.1002/slct.202103099  - Google Schoolar: search

Synthesis of 4-arylallylidenepyrazolones derivatives
Pyrazoles and their derivatives have attracted particular attention because they have a wide variety of biological activities, and recently, we found that 4,4’-(arylmethylene)-bis-(1-phenyl- 3-methyl-1H-pyrazole-5-ols) have good leishmanicidal activity against promastigotes of Leishmania mexicana....
year: 2021 - type: Artículos Publicados de Divulgación Internacional - journal: Chemistry Proceedings  - DOI: 10.3390/ecsoc-25-11714  - Google Schoolar: search

The Antioxidant and Hypoglycemic Properties and Phytochemical Profile of Clusia latipes Extracts
Introduction: The prevalence of diabetes has increased more rapidly in low and middleincome countries than in high-income countries. Type 2 diabetes mellitus (DM2), which is the most common form of diabetes, is caused by the inefficient use of insulin in the body and is characterized by disrupted...
year: 2020 - type: Scopus - journal: Pharmacognosy Journal  - DOI: 10.5530/pj.2020.12.21  - Google Schoolar: search

Cytotoxic property of Grias neuberthii extract on human colon cancer cells: A crucial role of autophagy
Traditional herbal medicine has become an important alternative in the treatment of various cancer types, including colon cancer, which represents one of the main health problems around the world. Therefore, the search for new therapies to counteract this disease is very active. Grias neuberthii is ...
year: 2020 - type: Scopus - journal: Evidence-based Complementary and Alternative Medicine  - DOI: 10.1155/2020/1565306  - Google Schoolar: search

Caracterización fitoquímica y elucidación estructural de metabolitos secundarios de Picramnia sp. en la Amazonía ecuatoriana.
planta, así como caracterizarlos mediante técnicas espectroscópicas. Se recolectaron las partes aéreas de la planta Picramnia sp. en la Reserva Biológica Jatun Sacha. Las hojas secas y molidas fueron maceradas consecutivamente en diferentes solventes, y algunos de los extractos obtenidos fueron...
year: 2020 - type: Latindex Catálogo - journal: InfoANALITICA  - DOI: https://doi.org/10.26807/ia.v8i2.129  - Google Schoolar: search

Phytochemistry and Bioactivity of Solanum betaceum Cav.
Solanum betaceum belongs to the Solanaceae family. Its fruit is mainly consumed in South America, but in recent years, it has been distributed to other regions. The different varieties of this fruit are closely linked to its components. Nutritionally, it is an excellent source of vitamin C and also ...
year: 2020 - type: Scopus - journal: Springer Science and Business Media B.V.  - DOI: 10.1007/978-3-030-30182-8_9  - Google Schoolar: search

Nanomedicamentos frente a la Leishmaniasis y el cáncer de colon.
La Leishmaniasis es una enfermedad zoonótica (se transmite de forma natural de los animales al ser humano) causada por protozoos del género Leishmania. En Ecuador es una dolencia que afecta principalmente como Leishmaniasis cutánea, pero que también puede aparecer como Leishmania visceral, se...
year: 2019 - type: Artículos Publicados de Divulgación Nacional - journal: Perspectivas  - Google Schoolar: search

Antioxidant properties of medicinal plants used in the Southern Ecuador
In this research, 64 organic extracts from 37 species, belonging to 23 botanical families of plants used in the folk medicine of southern Ecuador was study. The extracts analysed were obtained with different solvents (methanol, n-hexane, dichloromethane, ethyl acetate). The antioxidant activity wa...
year: 2018 - type: Artículos Publicados de Divulgación Internacional - journal: Journal of Pharmacognosy and Phytochemistry  - Google Schoolar: search

Phytochemical Study and Evaluation of the Cytotoxic Properties of Methanolic Extract from Baccharis obtusifolia
Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma ...
year: 2018 - type: ISI - journal: International Journal of Medicinal Chemistry  - DOI: 10.1155/2018/8908435  - Google Schoolar: search

Argentatin B derivatives induce cell cycle arrest and DNA damage in human colon cancer cells through p73/p53 regulation
The unique etiology of cancer requires a multi- dimensional approach for its treatment, control, and pre- vention. Therefore, all approaches to drug discovery and development should be exploited. Argentatin B (1)isa cycloartane triterpene isolated from Parthenium argentatum with inhibitory activity ...
year: 2018 - type: ISI - journal: Medicinal Chemistry Research  - DOI: 10.1007/s00044-017-2106-4  - Google Schoolar: search

Methoxyflavones from Marcetia taxifolia as HIV-1 Reverse Transcriptase Inhibitors
Methoxyflavones are flavonoid widely distributed in plants and has been reported as potent antitumor agents and some of them have shown activity against HIV-1. In this work, two methoxyflavones isolated from Marcetia taxifolia were evaluated in vitro and in silico as HIV-1 inhibitors. Pentamethoxyfl...
year: 2017 - type: Scopus - journal: Natural Product Communications   - Google Schoolar: search

Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells
Cell death is an innate capability of cells to be removed from microenvironment, if and when they are damaged by multiple stresses. Cell death is often regulated by multiple molecular pathways and mechanism, including apoptosis, autophagy, and necroptosis. The molecular network underlying these p...
year: 2017 - type: Scopus - journal: Current Genomics  - DOI: 10.2174/1389202917666160803150639  - Google Schoolar: search

Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies
Intestinal parasites delay mental and physical development in children. Infection with these parasites can result in complications during pregnancy and alter the health of newborns, which has long-term effects on educational attainment and economic productivity. The appearance of resistance against ...
year: 2017 - type: ISI - journal: European Journal of Medicinal Chemistry  - DOI: 10.1016/j.ejmech.2017.02.005  - Google Schoolar: search

Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador
Horchata is an herbal mixture infusion consumed in Southern Ecuador; 66% of its plants are anti-inflammatory medicinal plant, and 51% are analgesics. Anti-inflammatory substances can prevent carcinogenesis mediated by cytotoxic effects and can prevent DNA damage. The aim of this study was to evaluat...
year: 2017 - type: ISI - journal: BMC Complementary and Alternative Medicine  - DOI: 10.1186/s12906-017-2048-x  - Google Schoolar: search

Horchata drink in Southern Ecuador: Medicinal plants and people's wellbeing
The horchata is a herbal mixture infusion consumed in Southern Ecuador. It remains unknown how vendors group the plant species to sell them at traditional markets. This research documented the following: 1) a list of medicinal plant species sold for the drink; 2) the culturally important medicinal p...
year: 2017 - type: ISI - journal: Journal of Ethnobiology and Ethnomedicine  - DOI: 10.1186/s13002-017-0145-z  - Google Schoolar: search

Compuestos que se proyectan como fármacos anticancerosos y antiinflamatorios
Ecuador es un país rico en diversidad, sobre todo en flora. Dicha diversidad y los microclimas favorecen la producción de metabolitos secundarios, es decir, compuestos generados por las plantas que sirven, sobre todo, para protegerse de ambientes adversos, para determinar cuáles son las prop...
year: 2017 - type: Artículos Publicados de Divulgación Nacional - journal: Perspectivas  - Google Schoolar: search

Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies
Natural compounds from various plants, microorganisms and marine species play an important role in the discovery novel components that can be successfully used in numerous biomedical applications, including anticancer therapeutics. Since uncontrolled and rapid cell division is a hallmark of cancer, ...
year: 2017 - type: ISI - journal: Current Genomics  - DOI: 10.2174/1389202917666160808125645  - Google Schoolar: search

The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro
Abstract Background: Plant extracts are sources of valuable compounds with biological activity, especially for the antiproliferative activity against pathogens or tumor cells. Myricetin is a flavonoid found in several plants that has been described as an inhibitor of Human immunodeficiency virus typ...
year: 2017 - type: Scopus - journal: AIDS Research and Therapy  - DOI: 10.1186/s12981-017-0183-6  - Google Schoolar: search

A new indole-alkaloid and a new phenolic-glycoside with cytotoxic activity from Strychnos fendleri
A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the bark and leaves of Strychnos fendleri Sprague & Sandwith, together with six known compounds reported for the first time in this species. The structures of these compounds were determined on the basis of s...
year: 2016 - type: Scopus - journal: Natural Product Research  - DOI: 10.1080/14786419.2015.1019351  - Google Schoolar: search

Medicinal plants sold at traditional markets in southern Ecuador
The traditional markets in southern Ecuador and within the Andean region are especially important for plant resource trading among local people, even since before Spanish colonization; therefore, ethnobotanical studies are currently necessary and important. These strategic spaces persist for the tra...
year: 2016 - type: ISI - journal: Journal of Ethnobiology and Ethnomedicine  - DOI: 10.1186/s13002-016-0100-4  - Google Schoolar: search

Phytochemistry and Ethnopharmacology of the Ecuadorian Flora. A Review
Ecuador owns a considerable high quantity of wealthy ecosystems that contain an elevated biodiversity in flora and fauna. The use of native medicinal plants has been maintained by at least 18 different indigenous cultures; furthermore this country has been the witness of the discovery of important m...
year: 2016 - type: ISI - journal: Natural Product Communications  - DOI: 10.1177/1934578x1601100307  - Google Schoolar: search

Phytochemical study and evaluation of cytotoxic and genotoxic properties of extracts from Clusia latipes leaves
Some species of the Clusia genus have been shown to have important biomedical properties, including the ability to inhibit tumor growth in vitro and the usefulness for skin care. In this study, we exam-ined the cytotoxic effect of hexane, ethyl acetate and methanol extracts from Clusia latipes Planc...
year: 2016 - type: Scopus - journal: Revista Brasileira de Farmacognosia  - DOI: 10.1016/j.bjp.2015.08.014  - Google Schoolar: search

Cytotoxic and genotoxic effects of extracts from Annona montana M. fruit
Pulverized immature fruits of Annona montana M. are commonly used for biomedical applications, especially in the treatment of dysentery. The aim of this study was to investigate whether hexane, ethyl acetate or methanol extracts of A. montana M. can be cytotoxic to human tumor cells or exhibit g...
year: 2016 - type: ISI - journal: Food and Agricultural Immunology  - DOI: 10.1080/09540105.2016.1148121  - Google Schoolar: search

The cytotoxic principle of Bejaria resinosa from Ecuador
Bejaria resinosa Mutis ex LF is also known as “pena de cerro” and is a plant species used traditionally by the Saraguro ethnic group in Ecuador to treat nervous system problems, swollen wounds and inflammations of the genital organs, as well liver diseases and cancer. The aim of this study was...
year: 2015 - type: EBSCO - journal: Journal of Pharmacognosy and Phytochemistry  - Google Schoolar: search

Synthesis and biological evaluation of caracasine acid derivatives
A series of caracasine acid (1) derivatives were synthesized and evaluated for their in vitro cytotoxicity on human cancer-derived cell lines MCF-7 and PC-3, as well as for other activities such as antibacterial, antileishmanial and antitrypanosomal activity. Compound 1 was more effective than any o...
year: 2015 - type: Scopus - journal: Bioorganic and Medicinal Chemistry  - DOI: 10.1016/j.bmc.2015.04.015  - Google Schoolar: search

Medicinal plants of Ecuador: a review of plants with anticancer potential and their chemical composition
Ecuador is well known for its biodiversity and its ancient richness. This review provides an overview of Ecuadorian plant species in terms of the ethnobotany and chemistry of natural products in relation to anticancer activity. Plant species were classified into two groups: (a) Ethnomedical species ...
year: 2015 - type: ISI - journal: Medicinal Chemistry Research  - DOI: 10.1007/s00044-015-1335-7  - Google Schoolar: search

Antibacterial and cytotoxic activity from the extract and fractions of a marine derived bacterium from the Streptomyces genus
Marine natural products are a rich source of potent, selective, and structurally novel compounds. Marine bacteria are considered the most promising source of biologically active compounds which can be applied to treat a wide range of diseases. Objective: The current study was designed to establish t...
year: 2015 - type: Scopus - journal: Pharmaceutical Biology  - DOI: 10.3109/13880209.2015.1010739  - Google Schoolar: search

Phytometabolite Dehydroleucodine induces cell cycle arrest, apoptosis, and DNA damage in human astrocytoma cells through p73/p53 regulation
Accumulating evidence supports the idea that secondary metabolites obtained from medicinal plants (phytometabolites) may be important contributors in the development of new chemotherapeutic agents to reduce the occurrence or recurrence of cancer. Our study focused on Dehydroleucodine (DhL), a sesqui...
year: 2015 - type: ISI - journal: PLoS ONE  - DOI: 10.1371/journal.pone.0136527  - Google Schoolar: search

Molecular docking studies of the antitumoral activity and characterization of new chalcone
Phytochemical investigation of Azorella madreporica led to the isolation of four known compounds and an unknown chalcone. The structure of the new compound was identified by spectroscopy, including two-dimensional NMR techniques and comparison with published spectral data. The antioxidant activity o...
year: 2015 - type: ISI - journal: Current Topics in Medicinal Chemistry  - DOI: 10.2174/1568026615666150427125033  - Google Schoolar: search

Synthesis, anti-inflammatory activity and modeling studies of cycloartane-type terpenes derivatives isolated from Parthenium argentatum
The 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced edema model in mice determined the antiinflammatory activities in vivo of argentatins A, B and D, the main cycloartenol-type triterpenes present in Parthenium argentatum. Our results showed that argentatin B (ED50 = 1.5 x 10(-4) mmol/ear) and ar...
year: 2014 - type: ISI - journal: Bioorganic and Medicinal Chemistry  - DOI: 10.1016/j.bmc.2014.10.028  - Google Schoolar: search

Development of anticancer drugs based on the hallmarks of tumor cells
Cancer remains a public health problem with a high unmet medical demand. However, in recent decades, the knowledge of several functional molecular and biological traits that distinguish tumor cells from normal cells, known as the hallmarks of cancer as described by Hannahan and Weinberg, has led to ...
year: 2014 - type: ISI - journal: Tumor Biology  - DOI: 10.1007/s13277-014-1649-y  - Google Schoolar: search

Cytotoxic effects of Fisturalin-3 and 11-Deoxyfisturalin-3 on Jurkat and U937 cell lines
Fisturalines are bromotyrosine compounds isolated from marine sponges. Previous studies have shown antineoplasic, antiviral and antibacterial effects in Vitro; however, the possible effects of these compounds in hematologic malignancies have not been assessed. Methods. In the present study, the anti...
year: 2013 - type: Scopus - journal: Biomedical Papers  - DOI: 10.5507/bp.2012.089  - Google Schoolar: search

Evaluation of effect on cell cycle, necrosis and antiproliferative activity in vivo of argentatin B
Previously we had demonstrated the antiproliferative activity (AA) of argentatin B (1) against several human cancer cell lines, however its action mechanism is not known. Now we wish to report the AA of 1 on RKO (colorectal) human cancer cell line and the plausible mechanism of 1 in this cell line. ...
year: 2012 - type: Artículos Publicados de Divulgación Internacional - journal: Biomedical Papers  - Google Schoolar: search

The marine sponge toxin agelasine B increases the intracellular Ca 2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)
In search for new drugs derived from natural products for the possible treatment of cancer, we studied the action of agelasine B, a compound purified from a marine sponge Agelas clathrodes. Methods: Agelasine B was purified from a marine sponge Agelas clathrodes and assayed for cytotoxicity by MTT o...
year: 2012 - type: Scopus - journal: Cancer Chemotherapy and Pharmacology  - DOI: 10.1007/s00280-011-1677-x  - Google Schoolar: search

The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells
ent-Kauranes are diterpene-type compounds commonly found in most plant species, especially from the Euphorbiaceae family. These compounds have been studied due to their anti-inflammatory and anti-tumor properties. Regulation of apoptosis, or programmed cell death, is commonly bypassed by tumoral cel...
year: 2011 - type: Scopus - journal: Apoptosis  - DOI: 10.1007/s10495-011-0638-5  - Google Schoolar: search

Composition and cytotoxic activity of essential oils from Croton matourensis and Croton micans from Venezuela
The chemical composition and cytotoxic activity of the essential oils extracted from leaves of Croton matourensis and flowers and leaves of Croton micans were investigated. GC-FID and GC-MS analysis revealed that forty six compounds comprised 95.5% of C. matourensis essential oil, with the main comp...
year: 2010 - type: Scopus - journal: Records of Natural Products  - Google Schoolar: search

Cytotoxic activity of seco-entkaurenes from Croton caracasana on human cancer cell lines
In the course of searching for bioactive compounds from Croton species from Venezuela, two seco-entkaurenes isolated from flowers of Croton caracasana were evaluated in vitro for their cytotoxicities by the MTT assay against nine human cancer cell lines. The IC50 were determined and values between 1...
year: 2009 - type: Scopus - journal: Natural Product Communications  - Google Schoolar: search

New antiinflammatory cycloart-23-ene-3β-ol from Senefelderopsis chibiriquetensis
1D and 2D NMR spectroscopic techniques were used to obtain the complete characterization of cycloart-23-ene-3β-ol (1), isolated from one of the two species of Senefelderopsis belonging to the Euphorbiaceae family. This is the first report, including the NMR data, of this anti-inflammatory steroid i...
year: 2008 - type: Scopus - journal: Natural Product Communications  - Google Schoolar: search

Antibacterial and cytotoxic activity of leaf essential oil of Croton malambo
The composition of the essential oil obtained from leaves of Croton malambo was determined by means of GC-MS analysis. The major compound present in the oil was found to be: methyl eugenol (94.2%); γ-bisabolene (1.3%), isoelemicin (0.8 %) and γ-curcumene (0.8%) were the minor compounds. The antiba...
year: 2008 - type: Scopus - journal: Journal of Essential Oil-Bearing Plants  - Google Schoolar: search

Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
Aqueous extract of the stem barks of Croton cuneatus Klotz (Euphorbiaceae) was investigated for hypoglycaemic activity in streptozotocin(STZ)-induced diabetic rats. Increasing doses of aqueous extract (6.5, 13, 26 and 52 mg/kg i.p.) were separately administered to groups of fasted normal and diabeti...
year: 2007 - type: Scopus - journal: Brazilian Journal of Pharmacognosy  - Google Schoolar: search

Anti-inflammatory activity of Croton cuneatus aqueous extract
The aqueous extract of Croton cuneatus Klotz. (Euphorbiaceae), was tested for its antinociceptive effects using chemical and thermal test models in mice. Anti-inflammatory activity was determined in Sprague-Dawley rats in a model of acute plantar inflammation induced by bovine serum albumin. Croton ...
year: 2006 - type: Scopus - journal: Journal of Ethnopharmacology  - DOI: 10.1016/j.jep.2005.10.006  - Google Schoolar: search

New cytotoxic isoflavone from the root bark of Brosimum utile
A new isoflavone 5,7,4′-trihydroxy-3′-(3-hydroxy-3-methylbutyl)isoflavone (isowigtheone hydrate) (1), together with six known isoflavones 2-7 and (-)epicatechin, were isolated from the root barks of Brosimum utile. Their structures were established on the basis of spectroscopic evidence. The in ...
year: 2005 - type: Scopus - journal: Natural Product Research  - DOI: 10.1080/14786410412331280014  - Google Schoolar: search

Cytotoxic and proapoptotic activity of ent-16β-17α- dihydroxykaurane on human mammary carcinoma cell line MCF-7
Here we describe the cytotoxic and proapoptotic effect of an ent-kaurane (ent-16β-17α-dihydroxykaurane), compound isolated from Croton malambo barks, on malignant cell growth. When MCF-7 mammary carcinoma cells were treated with increasing concentrations of the ent-kauranoid, its cytotoxic activit...
year: 2005 - type: Scopus - journal: Cancer Letters  - DOI: 10.1016/j.canlet.2004.07.009  - Google Schoolar: search

Three new glutarimide alkaloids from Croton cuneatus
Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolation of the new glutarimide alkaloids: julocrotol (1), isojulocrotol (2), and julocrotone (3) along with the known compounds julocrotonine (4), lichexanthone (5) and selin-11-en-4α-ol (6). The structures ...
year: 2004 - type: Scopus - journal: Natural Product Research  - DOI: 10.1080/14786410310001622004  - Google Schoolar: search

Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract
Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as "palomatias" or "torco" was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15 mg/kg i.p....
year: 2003 - type: Scopus - journal: Journal of Ethnopharmacology  - DOI: 10.1016/S0378-8741(03)00179-X  - Google Schoolar: search